Transcriptional regulators of arterial and venous identity in the developing mammalian embryo

The complex and hierarchical vascular network of arteries, veins, capillaries features considerable endothelial heterogeneity, yet the regulatory pathways directing arteriovenous specification, differentiation identity are still not fully understood. Recent advances in analysis endothelial-specific gene elements, single cell RNA sequencing (scRNA-seq) lineage tracing has both emphasized importance transcriptional regulation this process shed light on mechanism specification within endothelium. In review we discuss recent our understanding how cells acquire arterial venous role different transcription factors play process.